Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5
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چکیده
منابع مشابه
Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor
Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin beta, ...
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Importin α is recognized as a classical nuclear localization signal (cNLS) receptor which mediates nucleocytoplasmic transport. However, it rapidly accumulates in the nucleus in response to cellular stresses, including oxidative stress, causing a blockade of the classical nuclear import pathway. We set out to determine whether importin α performs roles in the nucleus after cellular exposure to ...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2017
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.ej17-0156